The broadcaster revived the series last year after an 11 year absence from our screens.
Adam Hills replaced original host William G. Stewart in four celebrity specials with broadcaster and comedian Sandi Toksvig taking over presenting duties for two series of non-celeb episodes.
Toksvig will return to front the three new series, two of which will be filmed in Glasgow before production moved to Manchester for the fifth run. Series three is set to air on Channel 4 this summer.
Ed de Burgh, Commissioning Editor for Entertainment at Channel 4 said, “Sandi is undoubtedly one of Britain’s toughest quiz mistresses and we are delighted to welcome both her and the show back to the channel for three more series.
“We look forward to seeing Britain’s smartest quiz minds take on the Fifteen To One challenge.”
Tom Blakeson, Chief Creative Officer at series producers Remedy Productions, said: “Fifteen to One is one of the UK’s most-loved quiz shows so we’re delighted that Channel 4 has commissioned three further series for the channel.
“We are absolutely thrilled to be able to confirm that the brilliant Sandi Toksvig will be back for another 100 episodes; her razor sharp wit makes her the perfect host for Britain’s brainiest quiz.”